University of Kentucky - The Graduate School - Center for Biomedical Engineering

Charles F. Knapp, Ph.D.

Center for Biomedical Engineering
Wenner-Gren Research Laboratory
University of Kentucky
Lexington, KY 40506-0070
Tel: (859) 257-2894
Fax: (859) 257-1856
Laboratory: Cardiovascular Laboratory

Biography:

Charles F. Knapp was born in Evansville, IN on March 28, 1940. He received the B.A. degree from St. Procopius College, Lisle, IL in 1962 and the B.S., M.S., and Ph.D. degrees from University of Notre Dame, IN, in 1963, 1965, and 1968 respectively.

He joined the faculty of the Department of Mechanical Engineering at the University of Kentucky, Lexington, in 1968, where he conducted biomedical engineering research in the Wenner-Gren Laboratory. He is presently Professor and Director of the University of Kentucky's Center for Biomedical Engineering. His current research interest is in understanding mechanisms associated with changes in autonomic regulation of cardiovascular function during hypo/hypertensive challenges.

Research Interests:

Biofluid Mechanics
Cardiovascular Regulation

PROFESSIONAL EXPERIENCE:

1968 - 74	Assistant Professor, Mechanical Engineering, University of Kentucky
1973 - 75	Chairperson, Biomedical Engineering Council, University of Kentucky
1974 - 85	Associate Professor, Mechanical Engineering, University of Kentucky
1985	Professor, Mechanical Engineering, University of Kentucky
1986 - 88	Associate Director of the Center for Biomedical Engineering, University of Kentucky
1987 - 88	Acting Director of the Center for Biomedical Engineering, University of Kentucky
1987 - 90	Director of Graduate Studies, Center for Biomedical Engineering, University of Kentucky
1988 - Present	Professor, Biomedical Engineering Program, Graduate School, University of Kentucky
1989 - 90	Interim Director, Center for Biomedical Engineering, University of Kentucky
1990 - 2003	Director, Center for Biomedical Engineering, University of Kentucky

SELECTED PUBLICATIONS/ABSTRACTS:

Richardson DR and CF Knapp. Microvascular Pressure Responses of 2nd Generation Rats Chronically Exposed to 2G Centrifugation. Aviat Space Environ Med. 48(3): 195-199, 1977.

Evans JM, CF Knapp and TR Lowery. Pressor Response Buffering by Beta Adrenergic and Cholinergic Vasodilation in Tranquilized Dog. Am J Physiol: (Heart and Circulation Physiol. 5(1):H165-173, 1979.

Bhattacharya A, CF Knapp, EP McCutcheon and JM Evans. Cardiac Responses of Dogs to Nonsynchronous and Heart Synchronous Whole Body Vibration. J Appl Physiol: Respirat Environ Exercise Physiol 46(3): 549-555, 1979.

Knapp CF, JM Evans, DC Randall and JA Marquis. Cardiovascular Responses in Canines During Low Frequency Acceleration. Am J Physiol (Heart and Circulation Physiol 12): H998-1009, 1982.

Evans JM, JN Funk, JB Charles, DC Randall and CF Knapp. Endurance Training in Dogs Increases Vascular Responsiveness to an a1 Agonist. J Appl Physiol, 65(2):625-632, 1988
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Randall DC, CF Knapp and JM Evans. Cardiovascular Responses of Cardiac Denervated and Normally Innervated Dogs to Low Frequency Acceleration. Am J Physiol 257 (Heart Circ Physiol 26):H511-H524, 1989.

Brown DR, DC Randall, CF Knapp, KC Lee and JD Yingling. Stability of the Heart Rate Power Spectrum Over Time in the Conscious Dog. FASEB J. 3: 1644-1650; 1989.

Evans JM, JN Funk, DC Randall and CF Knapp. Influence of Cardiac Innervation on Intrinsic Heart Rate in Dogs. Am J Physiol 258 (Heart Circ Physiol 27): H1132-1137, 1990.

Berk M, J Evans, CF Knapp, M Harrison, T Kotchen and AN DeMaria. Influence of Alteration in Loading Produced by Lower Body Negative Pressure on Blood Flow Acceleration. J Am Coll Cardiol, 15:1069-74, 1990.

Lai-Fook SJ, LV Brown, VS Maudgalya, CF Knapp and S Ganesan. Effects of Increased Acceleration on Regional Pressure in Dogs.J Appl Physiol., 1991.

Berk, MR, X Gongyuan, OL Kwan, CF Knapp, J Evans, T Kotchen, JM Kotchen and A DeMaria. Reduction of Left Ventricular Preload by Lower Body Negative Pressure Alters Doppler Transmitral Filling Patterns. J Am Coll Cardiol., 1990; 16:1387-92.

Wang M, JM Evans, PLC Fischer and CF Knapp. Spectral Patterns and Frequency Response Characteristics of Arterial Pressure in Heart Paced Dogs. IEEE Trans BME, 42(7), 708-717, 1995.

Salcido R, SB Fisher, JC Donofrio, M Bieschke, CF Knapp, R Liang, EK LeGrand and JM Carney. An Animal Model and Computer-Controlled Surface Pressure Delivery System for the Production of Pressure Ulcers. Journal of Rehabilitation Research and Development 32(2): 149-161, 1995.

Patwardhan AR, S Vallurupalli, JM Evans, EN Bruce and CF Knapp. Override of the Spontaneous Respiratory Pattern Generator Reduces Cardiac Parasympathetic Influence. J Applied Physiology, 79:1048-54, 1995.

Patwardhan AR, JM Evans, EN Bruce, DL Eckberg and CF Knapp. Voluntary Control of Respiration Does Not Alter Vagal Modulation of Heart Rate. J Applied Physiology. 78(6):2087-2094, 1995.

Patwardhan AR, JM Evans, M Berk, KJ Grande and CF Knapp. Spectral Indices of Cardiovascular Adaptations to Short Term Simulated Microgravity Exposure. Integrative Physiological and Behavioral Science, 30:201-14, 1995.

Patwardhan AR, JM Evans, MR Berk and CF Knapp. Comparison of Heart Rate and Arterial Pressure Spectra During Head Up Tilt and a Matched Level of LBNP. Aviat Space, and Environmental Medicine, 66:865-71, 1995.

Wang M, J Evans L Hassebrook and CF Knapp. An Optimized Index of Human Cardiovascular Adaptation to Simulated Weightlessness. IEEE Transaction on Biomedical Engineering, 43(5):1-10, 1996.

Wang M, L Hassebrook, J Evans and CF Knapp. A Multistage Optimally Active Contour. IEEE Transaction on Image Processing, 5(11):1586-1591, 1996.

Knapp CF, CM McIntosh, KR King, JB Ott, CS Kim, FM Leonelli, MG Ziegler and JM Evans. Epinephrine/Norepinephrine Balance in Syncopal and Nonsyncopal Women. Experimental Biology 1997 (Abstract)

Patwardhan AR, S Vallurupalli, JM Evans, CF Knapp, EN Bruce. Use of Amplitude-Modulated Breathing for Assessment of Cardio-respiratory Frequency Response Within Subrespiratory Frequencies. IEEE Trans. on BME. 1998, 45; 268-273

Herrman E, CF Knapp, J Donofrio, R Salcido. Skin Perfusion Responses to Surface Pressure Before and After Ischemia: Implication for the Developing Pressure Ulcer. Journal of Rehab Research and Development 36(2):109-120, 1999.

Patel S, CF Knapp, JC Donofrio and R Salcido. Temperature Effects on Surface Pressure-Induced Changes in Rat Skin Perfusion: Implications in Pressure Ulcer Development. Journal of Rehabilitation Research and Development, 36 (3), 1999.

Evans, JM, CM McIntosh, AR Patwardhan, FM Leonelli and CF Knapp. Plasma Filtration Rate and Syncope in Young Healthy People During Lower Body Negative Pressure. Experimental Biology 2000 (Abstract).

Evans, JM, SR Simonson, CF Knapp, JM Stocks, HW Biagini, SA Cowell, KN Bailey, JM Vener, SN Evetts, FB Moore, MB Stenger, CM McIntosh and JE Greenleaf. Differences in Acceleration Training and Exercise Training on Resting Cardiovascular Variables. Experimental Biology 2000 (Abstract)

Park, A, B Charash, M Shaw, CF Knapp. Novel Application of Advanced Real Time Image Processing Techniques to Minimally Invasive Surgery. Society of American Gastrointestinal Endoscopic Surgeons 2000 (Abstract)

Charash, B, A Park, M Shaw, CF Knapp. Multiple Frame Integration Improves Visible Contrast Using Minimally Invasive Surgical Instruments. Central Surgical Association 2000 (Abstract)

Evans, JM, MB Stenger, E Kwong, CM McIntosh , DR Brown, AR Patwardhan, CF Knapp, SR Simonson, JM Stocks, HW Biagini, SA Cowell, KN Bailey, JM Vener, SN Evetts, FB Moore, and MG Ziegler.. Human Powered Centrifuge Training effects On Cardiovascular Responses to Head Up Tilt. Experimental Biology 2001 (Abstract)

Evans JM, FM Leonelli, MG Ziegler, CM McIntosh, AR Patwardhan, AC Ertl, CS Kim, and CF Knapp. Epinephrine, Vasodilation and Hemoconcentration In Syncopal, Healthy Men and Women. Autonom. Neurosci: Basic and Clin. 93: 2001.

Evans JM, A Patwardhan, M Ziegler, B Ott, C Kim, F Leonelli and CF Knapp. Gender Differences in Cardiovascular Autonomic Regulation: Spectral, Hormonal and Hemodynamic Indices. Jn. Appl. Physiol. 91: 2619-2626, 2001.

Patwardhan AR, Evans JM, Bruce EN, and CF Knapp. Heart rate variability during sympatho-excitatory challenges: Comparison between spontaneous and metronomic breathing. Int Physiol and Behav Sci.36(2): 109-120,2001.

Greenleaf JE, SR Simonson, JM Stocks, JM Evans and CF Knapp. Exercise Versus +Gz Acceleration Training. The 10th International Conference on Environmental Ergonomices, Fukuoka, Japan, 2002. (Abstract)

Greenleaf JE, S Simonson, J Stocks, J Evans, C Knapp, S Cowell, K Pemberton, H Wilson, J Vener, S Evetts, P Hardy, R Grindeland, H Hinghofer, S Smith, M Ziegler, DBrown, D Evans, F Moore and D Quatch. Effect of Exercise Training and +Gz Acceleration Training on Men. NASA/TM-2001-210926, 2001.

Stenger, MB, JM Evans, CF Knapp, E Kwong, CM McIntosh , SR Simonson, JM Stocks, FB Moore, MG Ziegler DR Brown, AR Patwardhan, KN Pemberton, JM Vener, SN Evetts, and JE Greenleaf. Differences between exercise training and. passive acceleration training on cardiovascular responses to head up tilt.FASEB Jnl 16 (4): A47.2002(Abstract)

Evans JM, MB Stenger, CF Knapp, AC Ertl, CM McIntosh and FM Leonelli. Venous pooling and plasma filtration in development of syncope before and after head down bedrest. FASEB Jnl 16 (4): A117. 2002 (Abstract)