Guoqiang Yu, Ph.D.

Biographical Information:

• 1996-1999 Ph.D. Candidate, Biomedical Engineering, Tianjin University, China
• 1999-2001 Research Scientist, PTB, Germany
• 2001-2002 Postdoctoral Fellow, Physics, University of Pennsylvania
• 2002-2004 Research Associate, Physics, University of Pennsylvania
• 2004-2006 Senior Research Investigator, Physics, University of Pennsylvania
• 2006-2007 Research Assistant Professor, Physics, University of Pennsylvania
• 2007- Assistant Professor, Center for BME, University of Kentucky

Research Interests:

• Biomedical Optics
• Light propagation in biological tissue
• Diffuse optical spectroscopy/imaging
• Probe-tissue interface
• Diagnosis of Tissue Disease with Light
• Muscle vascular disease (e.g. PAD)
• Diabetes
• Cancers (e.g. breast, head/neck, prostate)
• Stroke
• Brain/spinal cord injury
• Assessment of Treatment Effect
• Photodynamic therapy (PDT)
• Radiation therapy
• Chemotherapy
• Medicine therapy
• Surgical revascularization

Research Support:

• NIH: 1-R21-HL083225 Yu (PI)
• Assessment of Muscle Vascular Disease with Diffuse Light
• AHA Beginning Grant-in-Aid ( 0665446U) Yu (PI)
• Diffuse Optical Mapping Of Blood Flow, Oxygenation, and Metabolism in Ischemic Skeletal Muscle
• DOD New Investigator Award (W81XWH-04-1-0006) Yu (PI)
• Real-time Diffuse Optical Measurement for In-vivo PDT Dosimetry of Human Prostate
• NIH 1-R01-HL077699-01 Yu (co-PI)
• Diffuse Optical Imaging of Flow, Oxygenation and Metabolism in Brain

Awards and Honors:

• Second place winner of Young Investigators Awards Competition in 15 th annual meeting of the Society of Vascular Medicine Biology (SVMB, Anaheim, CA, June 2004)
• Best Poster Award in the Institute For Medicine AND Engineering (IME) Interdisciplinary Research Symposium (University of Pennsylvania, Philadelphia, PA, December, 2004)
• Second place winner of Young Investigators Awards Competition in 17 th annual meeting of the Society of Vascular Medicine Biology (SVMB, Philadelphia, PA, June 2006)
• Pending Patent # US 2006/0063995 A1: “Optical Measurement of Tissue Blood Flow Hemodynamics And Oxygenation”

Professional Affiliations:

• Optical Society of America (OSA)
• The International Society for Optical Engineering (SPIE)
• American Society of Photobiology (ASP)
• Society of Vascular Medicine Biology (SVMB)
• American College of Sports Medicine (ACSM)

Selected Recent Publications:

• Guoqiang Yu , Thomas F. Floyd, Turgut Durduran, Chao Zhou, John A. Detre, Arjun G. Yodh, “ Diffuse Correlation Spectroscopy for Muscle Blood Flow: Validation with Arterial-Spin-Labeling Perfusion MRI,” Optics Express, 15:1064-1075, 2007.
• U Sunar, S Makonnen, C Zhou, T Durduran, Guoqiang Yu, H  W Wang, W M Lee, and A G Yodh. Hemodynamic responses to antivascular therapy and ionizing radiation assessed by diffuse optical spectroscopies. Opt Expr, 15(23):15507-15516, 2007.
• Zhou C, Choe R, N Shah, T Durduran, Guoqiang Yu, A Durkin, D Hsiang, R Mehta, J Butler, A Cerussi, B J Tromberg, and A G Yodh. Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy. J Biomed Opt, 12(5):051903, 2007.
• G. Yu , T. Durduran, C. Zhou, T. C. Zhu, J. C. Finlay, T. M. Busch, S. B. Malkowicz, S. M. Hahn, A. G. Yodh, "Real-time In Situ Monitoring of Human Prostate Photodynamic Therapy with Diffuse Light," Photochem Photobiol, 82:1279-84, 2006.
• C Zhou, G Yu, D Furuya, J A Detre, J H Greenberg, A G Yodh, T Durduran, “Diffuse optical correlation tomography of cerebral blood flow during cortical spreading depression in rat brain,” Optics Express, 24:1125-44, 2006.
• G. Yu , T. Durduran, H.W. Wang, C. Zhou, M. E. Putt, H. M. Saunders, C. M. Sehgal, A. G. Yodh, T. M. Busch, “Noninvasive Monitoring of Murine Tumor Blood Flow During and After Photodynamic Therapy Provides Early Assessment of Therapeutic Efficacy”, Clinical Cancer Research, 11:3543-52, 2005.
• Guoqiang Yu , Turgut Durduran, Gwen Lech, Chao Zhou, Britton Chance, Arjun G. Yodh, “Time-dependent Blood Flow and Oxygenation in Human Skeletal Muscles Measured with Noninvasive Near-infrared Diffuse Optical Spectroscopies”, Journal of Biomedical Optics, 10:024027-1-12, 2005.
• T. Durduran, R. Choe, G. Yu, C. Zhou, J. C. Tchou, B. J. Czerniecki, A. G. Yodh. “Diffuse optical measurement of blood flow in breast tumors,” Optics Letters, 30:2915-2917, 2005.
• Durduran, T., Yu, G., Zhou, C., Detre, J., Greenberg, J., Burnett, M.G., Yodh A.G., “Diffuse optical measurement of blood flow, blood oxygenation and metabolism in human brain during sensorimotor cortex activation,” Optics Letters, 29:1766-1768 (2004).
• Turgut Durduran, Mark Burnett, Guoqiang Yu, John Detry, Joe H. Greenburg, Arjun G. Yodh, “Spatio-temporal quantification of blood flow during functional activation in rat somatosensory cortex using laser speckle flowmetry,” Journal of Cerebral Blood Flow and Metabolism, 518-25, 2004.
• Regine Choe, Turgut Durduran, Guoqiang Yu, Mark J. M. Nijland, Britton Chance, Arjun G. Yodh, Nirmala Ramanujam, “Transabdominal near infrared oximetry of hypoxic stress in fetal sheep brain in utero,” Proceedings of the National Academy of Sciences of the United States of America (PNAS), 100(22): 12950-4, 2003.
• Guoqiang Yu , T. Durduran, D. Furuya, J. H. Greenberg, A. G. Yodh, “Frequency-domain multiplexing system for in vivo diffuse light measurements of rapid cerebral hemodynamics,” Applied Optics, 42(16): 2931-9, 2003.